| Date | Competition | Opponents | Venue | Score | Goalscorers | Att | Rep | Vid |
|---|---|---|---|---|---|---|---|---|
| 07/08/2021 | Div 1 | LINCOLN CITY | H | 1-1 | Lloyd-McGoldrick | 4837 |  |  |
| 10/08/2021 | FLC1 | Crawley Town | A | 2-2 (10-9) | Sithole,Phillips | 1904 | | |
| 14/08/2021 | Div 1 | Plymouth Argyle | A | 0-1 | 10854 | | | |
| 17/08/2021 | Div 1 | AFC Wimbledon | A | 1-1 | OG | 7027 | | |
| 21/08/2021 | Div 1 | MORECAMBE | H | 2-1 | Carayol,Oliver(p) | 3789 | | |
| 24/08/2021 | FLC2 | CHELTENHAM TOWN | H | 1-1 (4-5) | Oliver | 2151 | | |
| 28/08/2021 | Div 1 | Shrewsbury Town | A | 1-2 | Tucker | 4625 | | |
| 11/09/2021 | Div 1 | Burton Albion | A | 1-1 | Oliver | 2555 | | |
| 18/09/2021 | Div 1 | MILTON KEYNES DONS | H | 1-4 | Oliver | 4119 | | |
| 21/09/2021 | Div 1 | CHARLTON ATHLETIC | H | 1-1 | OG | 7301 | | |
| 26/09/2021 | Div 1 | Oxford Utd | A | 1-1 | MacDonald | 6664 | | |
| 28/09/2021 | Div 1 | Cambridge Utd | A | 2-0 | Oliver,Lloyd-McGoldrick | 4019 | | |
| 02/10/2021 | Div 1 | WIGAN ATHLETIC | H | 0-2 | 4503 | | | |
| 09/10/2021 | Div 1 | Wycombe Wanderers | A | 0-2 | 4992 | | | |
| 16/10/2021 | Div 1 | SUNDERLAND | H | 1-2 | Lloyd-McGoldrick(p) | 6310 | | |
| 19/10/2021 | Div 1 | DONCASTER ROVERS | H | 1-0 | Oliver | 3713 | | |
| 23/10/2021 | Div 1 | Bolton Wanderers | A | 2-2 | Akinde,Dempsey | 13807 | | |
| 26/10/2021 | FLT Group | WEST HAM UTD U21 | H | 0-2 | 819 | | ||
| 30/10/2021 | Div 1 | ACCRINGTON STANLEY | H | 0-0 | 3609 | | | |
| 06/11/2021 | FAC1 | CHELTENHAM TOWN | H | 1-1 | Sithole | 2555 | | |
| 13/11/2021 | Div 1 | Sheffield Wednesday | A | 1-1 | Oliver | 20593 | | |
| 01/01/2022 | Div 1 | Milton Keynes Dons | A | 0-0 | 7891 | | | |
| 08/01/2022 | Div 1 | IPSWICH TOWN | H | 0-4 | 6401 | | | |
| 15/01/2022 | Div 1 | BURTON ALBION | H | 1-3 | McKenzie | 4198 | | |
| 22/01/2022 | Div 1 | Wigan Athletic | A | 2-3 | Reeves,O'Keefe | 9359 | | |
| 01/02/2022 | Div 1 | CREWE ALEXANDRA | H | 1-0 | Lloyd-McGoldrick(p) | 4917 | | |
| 05/02/2022 | Div 1 | Ipswich Town | A | 0-1 | 20698 | | | |
| 08/02/2022 | Div 1 | CAMBRIDGE UTD | H | 1-0 | Oliver | 3824 | | |
| 12/02/2022 | Div 1 | Morecambe | A | 1-1 | Jackson | 4499 | | |
| 19/02/2022 | Div 1 | PLYMOUTH ARGYLE | H | 0-2 | 5197 | | | |
| 22/02/2022 | Div 1 | AFC WIMBLEDON | H | 0-0 | 4151 | | | |
| 26/02/2022 | Div 1 | Lincoln City | A | 2-0 | Oliver,Thompson | 8208 | | |
| 05/03/2022 | Div 1 | BOLTON WANDERERS | H | 0-3 | 5109 | | | |
| 12/03/2022 | Div 1 | Doncaster Rovers | A | 1-0 | Kelman | 6920 | | |
| 15/03/2022 | Div 1 | Charlton Athletic | A | 0-1 | 9728 | | | |
| 19/03/2022 | Div 1 | SHEFFIELD WEDNESDAY | H | 0-0 | 7433 | | | |
| 26/03/2022 | Div 1 | Accrington Stanley | A | 2-1 | Kelman,Oliver | 2764 | | |
| 02/04/2022 | Div 1 | Sunderland | A | 0-1 | 31619 | | | |
| 09/04/2022 | Div 1 | WYCOMBE WANDERERS | H | 1-1 | Tucker | 4858 | | |
| 15/04/2022 | Div 1 | Cheltenham Town | A | 2-2 | Oliver,Reeves | 4415 | | |
| 18/04/2022 | Div 1 | FLEETWOOD TOWN | H | 0-0 | 8436 | | | |
| 23/04/2022 | Div 1 | Portsmouth | A | 1-3 | Jackson | 15540 | | |
| 30/04/2022 | Div 1 | ROTHERHAM UTD | H | 0-2 | 8542 | | |